IP6 + Inositol Nature Medicine for the Millennium eBook AbulKalam Shamsuddin
Download As PDF : IP6 + Inositol Nature Medicine for the Millennium eBook AbulKalam Shamsuddin 
Learn about the health benefits of the B vitamin Inositol and its derivative IP6, natural components of cereal grains such as rice, corn, wheat, sesame etc. Numerous laboratory and emerging clinical data prove that the combination has both preventive and therapeutic anti-cancer action. Other benefits extend to Alzheimer's disease, diabetes, kidney stone, heart disease, osteoporosis...
IP6 + Inositol Nature Medicine for the Millennium eBook AbulKalam Shamsuddin
Metastatic Prostate Cancer Patient with Two Bone MetastasesDr. Shamsuddin’s book “IP6 + Inositol: Nature’s Medicine for the Millennium!...” is absolutely essential reading for men and women who wish to prevent cancer, or fight cancer, and/or maintain a health status that deflects Alzheimer’s Disease, heart disease, kidney stones, osteoporosis, complications of diabetes, and numerous other illnesses. This University of Maryland Medical School professor grounds his education of the reader on his carefully designed laboratory experiments conducted during his long tenure on the faculty. Dr. Shamsuddin has been at the center of IP6 research for decades and knows the work of medical researchers worldwide, thereby enabling him to review a large number of studies confirming the benefits derived from a diet rich in inositol hexaphosphate (IP6) and inositol. I believe every person who reads “IP6 + Inositol…” carefully will conclude that it is essential for their home health library.
Perhaps, some facts concerning my personal journey with cancer will explain my enthusiasm for Dr. Shamsuddin’s book and its recommendations for a personal treatment plan. This reviewer is a retired 73 year old residing in the southwest with no heart attacks, strokes or major surgeries in his health history. I take two medications daily to manage my blood pressure. I exercise regularly and have not stopped exercising since I was first diagnosed in 2012.
In late November of 2012 shortly after 71st birthday my PSA suddenly shot up; the result, a score of 19, was double my usual score in the 7 to 9 range. My urologist told me, following a subsequent needle biopsy, that my Gleason Index score was an 8, “aggressive”, he said, as the range for that designation is a score of 8 to10. An MRI identified two bone metastases. My prostate had been diagnosed more than 15 years before as significantly enlarged, accompanied by typically high PSA scores. My fluctuating PSA scores triggered at least three needle biopsies over the years with all being negative. My biopsy in 2012 revealed cancer cells in all four quadrants of the prostate. My physician recommended I start hormone therapy immediately. My cancer was inoperable and incurable.
Throughout 2013 and 2014 I followed the recommended intermittent schedule of hormone therapy drugs. Six months on, six months off in order to extend the eventual onset of my developing drug resistance. Five years is the average time of hormone treatment for a prostate cancer patient with bone metastases before they expire. This cold fact provided ample motivation for a search for a supplementary medication, perhaps a natural substance that might augment the period of time that the cancer could be suppressed.
Shopping one day in a local supermarket, one that offers a large vitamin-supplement section, I asked a clerk about anticancer supplements. She suggested I investigate inositol. Her idea led me to the Amazon site and Dr. Shamsuddin’s marvelous book, which I quickly downloaded to my Kindle and read avidly. After completing the chapters on his family history and early research interests in colorectal cancer, I skimmed all the other cancer discussions and went directly to the information on prostate cancer. Once I got my most pressing questions answered, I reread the entire book four times. Though Dr. Shamsuddin incorporates biochemistry into his research reviews, the average reader, like myself, can skim over these passages and still get the guidance they need for answering their own questions about IP6 and inositol.
With the fast approaching date of August 28, 2015 for my six-month checkup on the efficacy of my hormone therapy drugs, I began a regimen of Dr. Shamsuddin’s “IP6 Gold” powder on July 12th. You will note when reading Dr. Shamsuddin’s book that he frequently cites a “dose-dependent” relationship being confirmed in the study under review; that is, the more IP6 blended with inositol administered to the subjects, compared to the other treatments being tested, the greater the observed beneficial effects. Therefore, I chose to take 3 scoops 4 times daily on an empty stomach, an unusually heavy dose that goes beyond Dr. Shamsuddin’s recommended treatment program in his book. The total of 12 scoops a day provides approximately 72 grams daily. I was convinced that I needed to test the dose dependency relationship at an extreme level as my prostate cancer had better than a two year head start on me. I felt it would be necessary to hit those malignant cells wherever they were very hard.
I have continued for the past two months with this regimen. I am pleased with my choice of the “IP-6 Gold” in a powder form as the large number of capsules required to equate with 12 scoops would be a burden to ingest every day. Also the powder is flavored “tropical fruit” and tasty when stirred into cold water. Occasionally, I use the Ocean Spray Diet cranberry blends to prevent flavor monotony. No adverse events have occurred at this dosage level. The only side effect is gas.
When I was first diagnosed n late 2012 I had asked my urologist “…are there any diet changes I should make? Are there supplements that could help?” He said there were not, but if I wanted to take some antioxidants, that would be fine. He was clearly pessimistic about there being any value in such diet changes.
On August 28, 2015 I met with him to assess my results after six months of taking the prescribed drugs. He walked into the exam room carrying his laptop and looking perplexed. I had not told him I had started taking IP6 + inositol.
My urologist appeared to be searching mentally for an explanation for today’s number, which turned out to be 0.1. At my prompting, he reviewed my numbers over the past two years. At the end of the first six-month cycle in mid-2013 it was 0.1 (I had started out with a PSA of 19 at diagnosis in late 2012). The second cycle of drug administration following the “resting” period in 2014 and indicated some hormone resistance building - my PSA was 0.2. (This negative trend by mid-2014 got my attention!)
Here it was August 2015 and my PSA of 8.9 in February 2015 was driven down to a 0.1, a level achieved two years ago when my system was first exposed to hormone therapy. After reviewing the past PSA numbers, he surprised me by asking for a digital rectal exam. He had not done this since my initial diagnosis in 2012. Following palpating the prostate, he remarked “your prostate is smooth …no hard nodules.” This seemed to leave him pleased but still puzzled. This was the second piece of data that did not fit into my clinical picture. He never asked me if I were doing anything differently in my diet.
At the close of the appointment, he asked in light of my results if I would schedule a six-month appointment – February 2016. This meant I would be skipping the typical 3-month follow up visit to assess progress. I was of course to suspend all medication. I asked him what he would be expecting in a PSA number in February 2016. He checked my history again and said he thought 6 to 8 was a likely range. He seemed happy with the visit. I certainly was and immediately called my wife when I got to the parking lot.
My intention is to share my IP6 regimen in the February meeting with him, assuming the numbers require explaining. When I got home, I thought about a passage in Dr. Shamsuddin’s book that summarized the research of Dr. Challa et al., on green tea extract compared to IP6 and inositol, and also combined with IP6 and inositol. Combined these three supplements, IP6, inositol, and green tea, have a synergistic effect (1+1+1=4). This prompted an online search that turned up numerous positive studies of green tea’s anticancer effects. (See pubmed.gov) With six months till my next meeting in February 2016, I decided to add a new supplement to my IP6 program. I found a decaffeinated green tea extract supplement online that offers a 725mg. capsule. I am now taking ten capsules a day, yielding a total intake of 7.25 grams daily. No side effects have been experienced with this new supplement.
With the grace of God, this posting will be updated following my February meeting.
UPDATE ON IP6 + INOSITOL TREATMENT March 3, 2016
You will recall that my physician asked me in August 2015 if I would skip my 3-month progress appointment and come back at the end of six months. I had that meeting with the urologist on February 26.
I prepared a summary of my IP6 regimen and brought a copy of Dr. Shamsuddin’s book that I felt certain he had not read. That turned out to be the case.
The doctor entered the exam room carrying his laptop and looked at the PSA report data. He told me my PSA had risen to 6.4 and that he was prepared to put me back on my six month hormone therapy schedule by giving me the anti-androgenic shot today and a new prescription for the daily pills. I responded by asking him to delay that treatment because I was taking IP6. I explained what that meant and asked if he had ever heard of it or Dr. Shamsuddin. He said he hadn’t which prompted me to hand him the summary sheet and the book, which I told him he could keep. He appeared very surprised but not displeased. He readily accepted the book. I did not emphasize that the 6.4 was consistent with the PSA scores I received for years prior to my cancer diagnosis in late 2012. (The high scores led to multiple needle biopsies, all negative, and were predicted by my enlarged prostate caused by BPH.) I wondered had I simply returned to my baseline number that indicated the cancer had been suppressed? Dr. Shamsuddin offers in his book excellent discussions of processes, such as cell normalization and cell apoptosis, that can help all readers regardless of the science background to understand how cancer cells are impacted by IP6.
My urologist suggested a six-week delay and wants to see if the number has gone significantly higher, indicating the cancer is resurgent. A cautious approach perhaps, but one I readily agreed with.
The summary sheet I gave him is provided below:
My IP6 regimen first consisted of 12 scoops of “IP6 Gold Powder” daily divided into 4 sessions of 3 scoops, and always on an empty stomach. This was modified after ninety days in mid-October 2015: from then to February, I took 2 scoops of IP6 + inositol powder 3 times a day for a total of six scoops– a dose that equates to 48 capsules daily. In October, I also began augmenting this core regimen with supplements identified in cancer research as being effective in experimental conditions; often prostate cancer specifically was studied in vivo and in vitro. These academic cancer research studies can be found at pubmed.gov. The adjunct supplements include,
1. Milk thistle extract (silymarin/silibinin), 5.4 grams daily
2. Decaf green tea extract, 13 grams daily
3. Grape seed extract, 2.4 grams daily
4. Resveratrol with red wine extract, 1.8 grams daily
5. Turmeric with BioPerine, 5.4 grams daily
The above supplements are in capsules and taken during my three IP6 dosing sessions and also with my three meals. I also began taking the following only with meals in October:
6. Delta fraction tocotrienols blended with (10%) gamma fraction tocotrienols, 375 mg. taken in capsules daily.
7. Genistein in capsules and also in unsweetened soy milk (4-6 cups daily) for a total of 215-250 mg. daily.
One last supplement is being taken by itself and always on an empty stomach:
8. Coriolus Versicolor (aka “turkey tail”) mushroom extract blended with Maitake D Fraction (10%) extract, 3 grams daily in tablets in two sessions.
I would encourage all who are taking IP-6 with additional supplements to investigate turmeric, DIM (di-indolyl methane), berberine, Vitamin K2, and melatonin.
UPDATE MARCH 28, 2017
Brief Review of where I am in my treatment program: With hormone therapy you typically go six months of hormones followed by six months of abstinence. At the end of each six month period a PSA reading is taken. The hormone cycle should result in a low PSA reading as the testosterone has been suppressed. When you develop a resistance to the hormones the PSA rises and when it reaches the high teens, low twenties metastasis begins. At the end of the six month abstinence period a PSA reading is taken and the hormones begin again. The medical rationale for the abstinence cycle is that the patient will not develop resistance as quickly and, therefore, their life of the patient will be extended. My first urologist said he once had a patient that went 8 years on hormone therapy. I have been on it 4 1/2 years.
Having relocated to Florida from Arizona, I found an excellent urologist who checked my PSA in September shortly after our moving. The PSA came in at 0.4. I went on the six month abstinence cycle and that concluded yesterday. My PSA was 5.0. That is below the typical PSA I had in my pre-cancer years. Why so high compared to the average man? I have an enlarged prostate (BPH diagnosis) and the PSA readings in the 6-8 range were consistent with the measured volume of my prostate. My doctor again palpated my prostate as he had last September: no discernible cancerous nodules. My doctor recommended a referral to the Moffitt Cancer Center for a new needle biopsy and radiology study to confirm the diagnosis of metastatic prostate cancer. Possible radiation treatment, which my first doctor in AZ said was not a appropriate because of the metastasis probably resulting in the spread of cancer cells throughout my body. My current urologist understands I am on massive doses daily of IP-6. Since last September I have been taking 6 scoops of Dr. Shamsuddin's Gold powder twice daily, AM and PM of course for a total of 12 scoops.
Three months ago I added 2 grams daily of Transfer Point's Beta 1, 3D Glucan. I emphasize the source on this product as the quality variations in this pharmaceutical are significant. To better understand this product go to vitawithimmunity online and view the different videos. Also read Dr. Vaclav Vetvicka's book "Beta Glucan: Nature's Secret", Third Edition. This is now the most significant, second-ranked I believe, supplement in my regimen. It must be taken, like IP-6, on an empty stomach. Dr. Vetvicka uses Transfer Point Beta 1,3D Glucan in his studies ( I noted this in a report on a BPH study he did in the Czech Republic in 2014. He is a research scientist at the University of Louisville's Medical School, the Pathology Department. Amazon has both the book and the Transfer Point product.
Finally, I should add that my urologist has dropped the casodex pills and will soon administer a six month Lupron shot.
UPDATE September 25, 2017
Since my last post I have been evaluated at Moffitt Cancer Center with the latest imaging technology. Surgical oncologists talked to me and recognized it was more appropriate for me to be seen by a medical oncologist given my advanced metastatic prostate cancer diagnosis. Two radiologic procedures (bone scan and MRI) were administered as the fundamental reason for my current urologist sending me to Moffitt was the aging of my imaging data (from late 2012). The two bone metastases that motivated my Arizona urologist to recommend immediate hormone therapy could not be detected. A lesion on my pelvic lymph node, however, was imaged. The medical oncologist believed the eligard/lupron medication was responsible for the bone metastases disappearing and declined to discuss inositol hexaphosphate (IP6) or any possible supplement effects on the these bone metastases. He said the lesion on the pelvic lymph node confirms a stage 4 metastatic cancer diagnosis. He expressed support for continuous Lupron therapy, and he considers it superior based on research results to the intermittent schedule my Arizona urologist preferred. He sent me back to my urologist and asked me to return when the disease becomes refractory. During the discussion I declined his offer of participation in a clinical trial as it would require my giving up all my supplements, to include IP6, Beta Glucan, Capsaicin, etc, etc.
Today I met with my urologist and he had the results of my most recent PSA test. It came in at 0.06. He was more surprised than I was and quite exuberant about this outcome. "You have made my day", he exclaimed. I must assume that is a number he does not often see. I have never had a PSA test that low. He believes it is all attributable to my Lupron shot in March. I have had this drug before and never had my PSA drop to this level. I must point out that my IP6 dose increased in March to 8 scoops twice a day, AM and PM for a total of 16. Yes, I realize that is a massive dose for those of you who take IP6. I am also now taking Beta Glucan #300 (from Transfer Point), 2,000 mg., once daily on a empty stomach. See Vaclav Vetvicka's text "Beta Glucan: Nature's Secret" (3rd edition at Amazon). I follow the Vetvicka protocol which recommends taking it with resveratrol and vitamin C. I also take 3,000 mg. daily of capsaicin/cayenne pepper. There are other supplements I take and they are cited above.
I would strongly urge any cancer patient to visit Michael Greger, MD, website, nutritionfacts.org. Prostate cancer patients in particular will find his videos on this subject very beneficial. This is not to say that women won't appreciate his many videos on breast cancer, etc. I have recently become a vegan because of his influence and lost 22 pounds in the first six weeks. I will continue to do portion control to lose another ten pounds at least.
UPDATE FEBRUARY 8, 2018
I will not have my next visit with my urologist until mid-March 2018. I am adding this note because of research I have found on milk thistle and cancer, specifically the studies done on prostate cancer. Somehow I have missed the thread of research being reported on milk thistle (silymarin, silibunin, and most importantly component chemicals isosylibin B and isosylibin A). The milk thistle supplements being sold are frequently deficient in the B and A chemical agents. This link will provide a readable summary of findings: https://www.lifeextensionvitamins.com/newwetofiprc.html
Please note that I am recommending based on findings that prostate cancer patients consider ADDING this natural supplement as adjuvant therapy, not replacing IP6 & Inositiol. The supplement company that seems to be out in front on formulation is Life Extension (sold on Amazon). They sell "European Milk Thistle with Isosylibin A and Isosylibin B". Dosage is a challenge. Apparently it has been used in a clinical trial with patients at 13,000 mg. in divided daily doses. I am continuing to search for more guidance on minimal dosage. Side effects reported are not apparently significant: mild laxative effect; however, women who are pregnant or who have a hormone-sensitive cancer must consult their physician. Please go to the drug advisory sites and review all the cautions. Good luck.
APRIL, 2018
I had a visit with my urologist concerning the PSA results. Surprisingly, the results were identical to the results obtained September, 2017! What were the odds of that happening: 0.06. He didn't know what to say beyond reminding me to have my 6 mos. Lupron shot (that's happened). He also said he wanted to measure my creatinine in the fall to see if the Lupron is having any negative effect.
My supplements have not changed. I have not previously mentioned red yeast rice for managing cholesterol. ( I have been taking it for 22 years.) It is now considered useful in fighting cancer based on a recently published study from Taiwan on life expectancy of men taking either simvastation (Zocor) or Lovastatin. Red yeast rice is the parent molecule for Lovastatin. CAUTION. If you are not now taking a statin be aware that red yeast capsules can have side effects like any statin. Talk to your physician and have him monitor you as you begin such a regimen. I take 2400 mgs. daily in divided AM and PM doses. I purchase the Solaray brand. Always take it with co-q-10 or ubiquinol. If you are already taking a statin drug or chol fighting drug, you will not be a candidate for red yeast rice. Again, talk to your physician.
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IP6 + Inositol Nature Medicine for the Millennium eBook AbulKalam Shamsuddin Reviews
Book provides good history of IP6 and evaluations of potential benefits of using the product. Many portions of the book were too technical to be understandable by a non-medically trained person. Wish it had more specifics about appropiate dosages for different types of cancer, and hereditary conditions. Overall the pluses of the book out-way the minuses.
I learned of ip6 many years ago but never really learned of the value of the product until recently after reading prof AbdulKalam's book on IP6. This is a must read if you want to enjoy healthy living, free from disease. If there is a silver bullet in health, learn about it in this book. The reading is a little technical, just stay with it and you"ll be rewarded.
This book answers the question why almost everyone needs to take IP6. It's understandable science and a treasure chest full of insights, observations, and studies about the application, function, and far-reaching benefits of IP6. It's written by the father of IP6 R&D. I only wish I had known about IP6 years ago, it could have spared me lots of avoidable infections. Wishing you all good health, Ernest, NYC
I am taking this for iron chelation because I have iron overload disease (hemachromatosis). It works. My iron level dropped 40 points in a month even though I did not change my diet. Try it. It is totally safe and cheap.
This is a thorough explanation of what IP6 +Inositol is made of. The only problem is it is written mostly in scientific terms. A lot of research on the layman's part. I still highly recommend the book because everyone should know what you are putting in your body. I found it has changed my mental attitude at least 80% toward positive thinking. I have several arthritis and this has gotten rid of most of the depression that comes with the pain of the disease.
I bought the book AFTER starting on the product after someone recommended the product to me based on a mass on my left breast. The mass started shrinking after using this product. I am forever grateful to the person for recommending the product to me...and also grateful that I bought this book to read to see the research. I started the product in 1/2015 - every night before going to bed on an empty stomach (4 hours after last anything but water by mouth). I noticed the mass was smaller 3-4 weeks after starting the product, and continued/continue taking daily. I had not realized my entire left breast had "hardened" like a football...because it crept into that state, I didn't really notice the difference between the two breasts. (Life stressors were working overtime on me and took my mind away from noticing I guess).
I continued taking the product (powder form mixed with room temp distilled water, 12-13 grams daily) and found that the hardness of my left breast changed to a supple form again. The mass at the top dissolved away and now I cannot detect it at all.
I lost my health insurance coverage in 7/2014 and could not afford to obtain any insurance after that time. I will continue to use this product as I believe in my hard that the mass above my breast and "hardened" breast were indicative of less than stellar breast health.
I was already using BioDim as a prophylactic along with Iodoral (25 mg) for the same purpose. Without a biopsy I cannot be sure of a true "Big C" Diagnosis....however, I have no explanation for the "retreat" of masses in my breast tissue and the only change made was the intake of IP6 w/inositol by mouth.
I won't be without IP6 w/inositol if I can help it. I would rather miss a meal than miss this product. 1 powder container lasts me for 2 weeks.
I could probably step down the intake amount, but with the results that I experienced, I am unsure I want to chance it until I can get a Breast Thermography and ultrasound. (My preference for breast health are those two vs. Mammography).
I was amazed when reading the book at all of the absolutely amazing benefits from this nutritional discovery!
Metastatic Prostate Cancer Patient with Two Bone Metastases
Dr. Shamsuddin’s book “IP6 + Inositol Nature’s Medicine for the Millennium!...” is absolutely essential reading for men and women who wish to prevent cancer, or fight cancer, and/or maintain a health status that deflects Alzheimer’s Disease, heart disease, kidney stones, osteoporosis, complications of diabetes, and numerous other illnesses. This University of Maryland Medical School professor grounds his education of the reader on his carefully designed laboratory experiments conducted during his long tenure on the faculty. Dr. Shamsuddin has been at the center of IP6 research for decades and knows the work of medical researchers worldwide, thereby enabling him to review a large number of studies confirming the benefits derived from a diet rich in inositol hexaphosphate (IP6) and inositol. I believe every person who reads “IP6 + Inositol…” carefully will conclude that it is essential for their home health library.
Perhaps, some facts concerning my personal journey with cancer will explain my enthusiasm for Dr. Shamsuddin’s book and its recommendations for a personal treatment plan. This reviewer is a retired 73 year old residing in the southwest with no heart attacks, strokes or major surgeries in his health history. I take two medications daily to manage my blood pressure. I exercise regularly and have not stopped exercising since I was first diagnosed in 2012.
In late November of 2012 shortly after 71st birthday my PSA suddenly shot up; the result, a score of 19, was double my usual score in the 7 to 9 range. My urologist told me, following a subsequent needle biopsy, that my Gleason Index score was an 8, “aggressive”, he said, as the range for that designation is a score of 8 to10. An MRI identified two bone metastases. My prostate had been diagnosed more than 15 years before as significantly enlarged, accompanied by typically high PSA scores. My fluctuating PSA scores triggered at least three needle biopsies over the years with all being negative. My biopsy in 2012 revealed cancer cells in all four quadrants of the prostate. My physician recommended I start hormone therapy immediately. My cancer was inoperable and incurable.
Throughout 2013 and 2014 I followed the recommended intermittent schedule of hormone therapy drugs. Six months on, six months off in order to extend the eventual onset of my developing drug resistance. Five years is the average time of hormone treatment for a prostate cancer patient with bone metastases before they expire. This cold fact provided ample motivation for a search for a supplementary medication, perhaps a natural substance that might augment the period of time that the cancer could be suppressed.
Shopping one day in a local supermarket, one that offers a large vitamin-supplement section, I asked a clerk about anticancer supplements. She suggested I investigate inositol. Her idea led me to the site and Dr. Shamsuddin’s marvelous book, which I quickly downloaded to my and read avidly. After completing the chapters on his family history and early research interests in colorectal cancer, I skimmed all the other cancer discussions and went directly to the information on prostate cancer. Once I got my most pressing questions answered, I reread the entire book four times. Though Dr. Shamsuddin incorporates biochemistry into his research reviews, the average reader, like myself, can skim over these passages and still get the guidance they need for answering their own questions about IP6 and inositol.
With the fast approaching date of August 28, 2015 for my six-month checkup on the efficacy of my hormone therapy drugs, I began a regimen of Dr. Shamsuddin’s “IP6 Gold” powder on July 12th. You will note when reading Dr. Shamsuddin’s book that he frequently cites a “dose-dependent” relationship being confirmed in the study under review; that is, the more IP6 blended with inositol administered to the subjects, compared to the other treatments being tested, the greater the observed beneficial effects. Therefore, I chose to take 3 scoops 4 times daily on an empty stomach, an unusually heavy dose that goes beyond Dr. Shamsuddin’s recommended treatment program in his book. The total of 12 scoops a day provides approximately 72 grams daily. I was convinced that I needed to test the dose dependency relationship at an extreme level as my prostate cancer had better than a two year head start on me. I felt it would be necessary to hit those malignant cells wherever they were very hard.
I have continued for the past two months with this regimen. I am pleased with my choice of the “IP-6 Gold” in a powder form as the large number of capsules required to equate with 12 scoops would be a burden to ingest every day. Also the powder is flavored “tropical fruit” and tasty when stirred into cold water. Occasionally, I use the Ocean Spray Diet cranberry blends to prevent flavor monotony. No adverse events have occurred at this dosage level. The only side effect is gas.
When I was first diagnosed n late 2012 I had asked my urologist “…are there any diet changes I should make? Are there supplements that could help?” He said there were not, but if I wanted to take some antioxidants, that would be fine. He was clearly pessimistic about there being any value in such diet changes.
On August 28, 2015 I met with him to assess my results after six months of taking the prescribed drugs. He walked into the exam room carrying his laptop and looking perplexed. I had not told him I had started taking IP6 + inositol.
My urologist appeared to be searching mentally for an explanation for today’s number, which turned out to be 0.1. At my prompting, he reviewed my numbers over the past two years. At the end of the first six-month cycle in mid-2013 it was 0.1 (I had started out with a PSA of 19 at diagnosis in late 2012). The second cycle of drug administration following the “resting” period in 2014 and indicated some hormone resistance building - my PSA was 0.2. (This negative trend by mid-2014 got my attention!)
Here it was August 2015 and my PSA of 8.9 in February 2015 was driven down to a 0.1, a level achieved two years ago when my system was first exposed to hormone therapy. After reviewing the past PSA numbers, he surprised me by asking for a digital rectal exam. He had not done this since my initial diagnosis in 2012. Following palpating the prostate, he remarked “your prostate is smooth …no hard nodules.” This seemed to leave him pleased but still puzzled. This was the second piece of data that did not fit into my clinical picture. He never asked me if I were doing anything differently in my diet.
At the close of the appointment, he asked in light of my results if I would schedule a six-month appointment – February 2016. This meant I would be skipping the typical 3-month follow up visit to assess progress. I was of course to suspend all medication. I asked him what he would be expecting in a PSA number in February 2016. He checked my history again and said he thought 6 to 8 was a likely range. He seemed happy with the visit. I certainly was and immediately called my wife when I got to the parking lot.
My intention is to share my IP6 regimen in the February meeting with him, assuming the numbers require explaining. When I got home, I thought about a passage in Dr. Shamsuddin’s book that summarized the research of Dr. Challa et al., on green tea extract compared to IP6 and inositol, and also combined with IP6 and inositol. Combined these three supplements, IP6, inositol, and green tea, have a synergistic effect (1+1+1=4). This prompted an online search that turned up numerous positive studies of green tea’s anticancer effects. (See pubmed.gov) With six months till my next meeting in February 2016, I decided to add a new supplement to my IP6 program. I found a decaffeinated green tea extract supplement online that offers a 725mg. capsule. I am now taking ten capsules a day, yielding a total intake of 7.25 grams daily. No side effects have been experienced with this new supplement.
With the grace of God, this posting will be updated following my February meeting.
UPDATE ON IP6 + INOSITOL TREATMENT March 3, 2016
You will recall that my physician asked me in August 2015 if I would skip my 3-month progress appointment and come back at the end of six months. I had that meeting with the urologist on February 26.
I prepared a summary of my IP6 regimen and brought a copy of Dr. Shamsuddin’s book that I felt certain he had not read. That turned out to be the case.
The doctor entered the exam room carrying his laptop and looked at the PSA report data. He told me my PSA had risen to 6.4 and that he was prepared to put me back on my six month hormone therapy schedule by giving me the anti-androgenic shot today and a new prescription for the daily pills. I responded by asking him to delay that treatment because I was taking IP6. I explained what that meant and asked if he had ever heard of it or Dr. Shamsuddin. He said he hadn’t which prompted me to hand him the summary sheet and the book, which I told him he could keep. He appeared very surprised but not displeased. He readily accepted the book. I did not emphasize that the 6.4 was consistent with the PSA scores I received for years prior to my cancer diagnosis in late 2012. (The high scores led to multiple needle biopsies, all negative, and were predicted by my enlarged prostate caused by BPH.) I wondered had I simply returned to my baseline number that indicated the cancer had been suppressed? Dr. Shamsuddin offers in his book excellent discussions of processes, such as cell normalization and cell apoptosis, that can help all readers regardless of the science background to understand how cancer cells are impacted by IP6.
My urologist suggested a six-week delay and wants to see if the number has gone significantly higher, indicating the cancer is resurgent. A cautious approach perhaps, but one I readily agreed with.
The summary sheet I gave him is provided below
My IP6 regimen first consisted of 12 scoops of “IP6 Gold Powder” daily divided into 4 sessions of 3 scoops, and always on an empty stomach. This was modified after ninety days in mid-October 2015 from then to February, I took 2 scoops of IP6 + inositol powder 3 times a day for a total of six scoops– a dose that equates to 48 capsules daily. In October, I also began augmenting this core regimen with supplements identified in cancer research as being effective in experimental conditions; often prostate cancer specifically was studied in vivo and in vitro. These academic cancer research studies can be found at pubmed.gov. The adjunct supplements include,
1. Milk thistle extract (silymarin/silibinin), 5.4 grams daily
2. Decaf green tea extract, 13 grams daily
3. Grape seed extract, 2.4 grams daily
4. Resveratrol with red wine extract, 1.8 grams daily
5. Turmeric with BioPerine, 5.4 grams daily
The above supplements are in capsules and taken during my three IP6 dosing sessions and also with my three meals. I also began taking the following only with meals in October
6. Delta fraction tocotrienols blended with (10%) gamma fraction tocotrienols, 375 mg. taken in capsules daily.
7. Genistein in capsules and also in unsweetened soy milk (4-6 cups daily) for a total of 215-250 mg. daily.
One last supplement is being taken by itself and always on an empty stomach
8. Coriolus Versicolor (aka “turkey tail”) mushroom extract blended with Maitake D Fraction (10%) extract, 3 grams daily in tablets in two sessions.
I would encourage all who are taking IP-6 with additional supplements to investigate turmeric, DIM (di-indolyl methane), berberine, Vitamin K2, and melatonin.
UPDATE MARCH 28, 2017
Brief Review of where I am in my treatment program With hormone therapy you typically go six months of hormones followed by six months of abstinence. At the end of each six month period a PSA reading is taken. The hormone cycle should result in a low PSA reading as the testosterone has been suppressed. When you develop a resistance to the hormones the PSA rises and when it reaches the high teens, low twenties metastasis begins. At the end of the six month abstinence period a PSA reading is taken and the hormones begin again. The medical rationale for the abstinence cycle is that the patient will not develop resistance as quickly and, therefore, their life of the patient will be extended. My first urologist said he once had a patient that went 8 years on hormone therapy. I have been on it 4 1/2 years.
Having relocated to Florida from Arizona, I found an excellent urologist who checked my PSA in September shortly after our moving. The PSA came in at 0.4. I went on the six month abstinence cycle and that concluded yesterday. My PSA was 5.0. That is below the typical PSA I had in my pre-cancer years. Why so high compared to the average man? I have an enlarged prostate (BPH diagnosis) and the PSA readings in the 6-8 range were consistent with the measured volume of my prostate. My doctor again palpated my prostate as he had last September no discernible cancerous nodules. My doctor recommended a referral to the Moffitt Cancer Center for a new needle biopsy and radiology study to confirm the diagnosis of metastatic prostate cancer. Possible radiation treatment, which my first doctor in AZ said was not a appropriate because of the metastasis probably resulting in the spread of cancer cells throughout my body. My current urologist understands I am on massive doses daily of IP-6. Since last September I have been taking 6 scoops of Dr. Shamsuddin's Gold powder twice daily, AM and PM of course for a total of 12 scoops.
Three months ago I added 2 grams daily of Transfer Point's Beta 1, 3D Glucan. I emphasize the source on this product as the quality variations in this pharmaceutical are significant. To better understand this product go to vitawithimmunity online and view the different videos. Also read Dr. Vaclav Vetvicka's book "Beta Glucan Nature's Secret", Third Edition. This is now the most significant, second-ranked I believe, supplement in my regimen. It must be taken, like IP-6, on an empty stomach. Dr. Vetvicka uses Transfer Point Beta 1,3D Glucan in his studies ( I noted this in a report on a BPH study he did in the Czech Republic in 2014. He is a research scientist at the University of Louisville's Medical School, the Pathology Department. has both the book and the Transfer Point product.
Finally, I should add that my urologist has dropped the casodex pills and will soon administer a six month Lupron shot.
UPDATE September 25, 2017
Since my last post I have been evaluated at Moffitt Cancer Center with the latest imaging technology. Surgical oncologists talked to me and recognized it was more appropriate for me to be seen by a medical oncologist given my advanced metastatic prostate cancer diagnosis. Two radiologic procedures (bone scan and MRI) were administered as the fundamental reason for my current urologist sending me to Moffitt was the aging of my imaging data (from late 2012). The two bone metastases that motivated my Arizona urologist to recommend immediate hormone therapy could not be detected. A lesion on my pelvic lymph node, however, was imaged. The medical oncologist believed the eligard/lupron medication was responsible for the bone metastases disappearing and declined to discuss inositol hexaphosphate (IP6) or any possible supplement effects on the these bone metastases. He said the lesion on the pelvic lymph node confirms a stage 4 metastatic cancer diagnosis. He expressed support for continuous Lupron therapy, and he considers it superior based on research results to the intermittent schedule my Arizona urologist preferred. He sent me back to my urologist and asked me to return when the disease becomes refractory. During the discussion I declined his offer of participation in a clinical trial as it would require my giving up all my supplements, to include IP6, Beta Glucan, Capsaicin, etc, etc.
Today I met with my urologist and he had the results of my most recent PSA test. It came in at 0.06. He was more surprised than I was and quite exuberant about this outcome. "You have made my day", he exclaimed. I must assume that is a number he does not often see. I have never had a PSA test that low. He believes it is all attributable to my Lupron shot in March. I have had this drug before and never had my PSA drop to this level. I must point out that my IP6 dose increased in March to 8 scoops twice a day, AM and PM for a total of 16. Yes, I realize that is a massive dose for those of you who take IP6. I am also now taking Beta Glucan #300 (from Transfer Point), 2,000 mg., once daily on a empty stomach. See Vaclav Vetvicka's text "Beta Glucan Nature's Secret" (3rd edition at ). I follow the Vetvicka protocol which recommends taking it with resveratrol and vitamin C. I also take 3,000 mg. daily of capsaicin/cayenne pepper. There are other supplements I take and they are cited above.
I would strongly urge any cancer patient to visit Michael Greger, MD, website, nutritionfacts.org. Prostate cancer patients in particular will find his videos on this subject very beneficial. This is not to say that women won't appreciate his many videos on breast cancer, etc. I have recently become a vegan because of his influence and lost 22 pounds in the first six weeks. I will continue to do portion control to lose another ten pounds at least.
UPDATE FEBRUARY 8, 2018
I will not have my next visit with my urologist until mid-March 2018. I am adding this note because of research I have found on milk thistle and cancer, specifically the studies done on prostate cancer. Somehow I have missed the thread of research being reported on milk thistle (silymarin, silibunin, and most importantly component chemicals isosylibin B and isosylibin A). The milk thistle supplements being sold are frequently deficient in the B and A chemical agents. This link will provide a readable summary of findings https//www.lifeextensionvitamins.com/newwetofiprc.html
Please note that I am recommending based on findings that prostate cancer patients consider ADDING this natural supplement as adjuvant therapy, not replacing IP6 & Inositiol. The supplement company that seems to be out in front on formulation is Life Extension (sold on ). They sell "European Milk Thistle with Isosylibin A and Isosylibin B". Dosage is a challenge. Apparently it has been used in a clinical trial with patients at 13,000 mg. in divided daily doses. I am continuing to search for more guidance on minimal dosage. Side effects reported are not apparently significant mild laxative effect; however, women who are pregnant or who have a hormone-sensitive cancer must consult their physician. Please go to the drug advisory sites and review all the cautions. Good luck.
APRIL, 2018
I had a visit with my urologist concerning the PSA results. Surprisingly, the results were identical to the results obtained September, 2017! What were the odds of that happening 0.06. He didn't know what to say beyond reminding me to have my 6 mos. Lupron shot (that's happened). He also said he wanted to measure my creatinine in the fall to see if the Lupron is having any negative effect.
My supplements have not changed. I have not previously mentioned red yeast rice for managing cholesterol. ( I have been taking it for 22 years.) It is now considered useful in fighting cancer based on a recently published study from Taiwan on life expectancy of men taking either simvastation (Zocor) or Lovastatin. Red yeast rice is the parent molecule for Lovastatin. CAUTION. If you are not now taking a statin be aware that red yeast capsules can have side effects like any statin. Talk to your physician and have him monitor you as you begin such a regimen. I take 2400 mgs. daily in divided AM and PM doses. I purchase the Solaray brand. Always take it with co-q-10 or ubiquinol. If you are already taking a statin drug or chol fighting drug, you will not be a candidate for red yeast rice. Again, talk to your physician.
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